Alpha-2 adrenoceptor agonists and sepsis: improved survival?
نویسندگان
چکیده
منابع مشابه
Alpha-2 adrenoceptor agonists and sepsis: improved survival?
mended for segregating the eff ect of dexmedetomidine, an alpha-2 adrenoceptor agonist, in sepsis [1]. However, three questions arise from their study: what are the Pvalues for the data reported in Table 1? Why was there such a discrepancy between the fentanyl dose given to patients on dexmedetomidine and those on lorazepam (1,114 versus 117 μg/day, P = 0.01) considering the 50 to 80% reduction...
متن کاملEffects of alpha 2-adrenoceptor agonists dexmedetomidine and guanfacine on morphine analgesia and tolerance in rats
BACKGROUND Alpha 2 (α(2))-adrenoceptor agonists may be useful for their potential to increase or prolong opioid analgesia while attenuating the development of opioid tolerance. The purpose of this study was to investigate the effects of dexmedetomidine and guanfacine (α(2)-adrenoceptor agonists) on morphine analgesia and tolerance in rats. METHODS Adult male Wistar albino rats weighing 195-20...
متن کاملSequential Binding of Agonists to the 2 Adrenoceptor
The 2 adrenoreceptor ( 2AR) is a prototypical G protein-coupled receptor (GPCR) activated by catecholamines. Agonist activation of GPCRs leads to sequential interactions with heterotrimeric G proteins, which activate cellular signaling cascades, and with GPCR kinases and arrestins, which attenuate GPCRmediated signaling. We used fluorescence spectroscopy to monitor catecholamine-induced conform...
متن کاملalpha(2)-Adrenoceptor agonists inhibit vitreal glutamate and aspartate accumulation and preserve retinal function after transient ischemia.
Recent studies have suggested that alpha(2)-adrenergic agonists prevent neuronal cell death in a number of animal models, although the mechanism of alpha(2)-neuroprotection remains unclear. In a retinal ischemia model, the alpha(2)-specific agonist brimonidine (1 mg/kg i.p.) preserves approximately 80% of the electroretinogram (ERG) b-wave. The protective effect of brimonidine is completely blo...
متن کاملIn vivo effects of alpha-adrenoceptor agonists and antagonists on pial veins of cats.
Cerebral blood volume and intracranial pressure may be modified by influences on cerebral veins. The known adrenergic innervation of cerebral veins and their sensitivity to norepinephrine raised the question, whether pial veins can be selectively influenced through adrenoceptors in vivo. Therefore, alpha 1 and alpha 2 adrenoceptor agonists and antagonists were locally injected into the perivasc...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Critical Care
سال: 2010
ISSN: 1364-8535
DOI: 10.1186/cc9096